Global governance is a challenge of our era and us as human beings no matter where we live and what values we believe in. After one hundred years of development, international relations are so closely and tightly knit. A problem in a community might affect the life of the people in a remote part of the world and its solution might also be in the hands of these people. But can’t be assumed outside the more global International Relations theories and practices approach, an interrelated already practiced at every policy decision making, economic and financial levels and first of all by the main international powers and players. How can we manage this complex of various relations and how the outcome matters for our life and common future? It is the time for us to invest our wisdom and energy to make global governance work now and to give a sense to the United Nations already reduced to a zero-sum-game, simply playing on the major emergencies and conflicts. Because, just to mention first the obsolete veto system that would be at least extended to all the 15 countries of the Security Council, both permanent or at rotation, with the weighting of votes bringing less hypocrite the present five Jalta powers partition already 70 years ago. We are talking of a world that is not existing anymore, dissolved in the passage to the third millennium but with UN moving as in the previous century. There is no simple way and framework for global governance. Global governance is a general term which means to think globally and act globally. It is complicated because problems might be local but even so assuming quite often a global political relevance that transforms them into a global issue and the connected challenges. The solution might be then achieved in national or regional groups of States but very often they escalate to continental or global international relevance. We need to sort out which solutions are the best for the problems or conflicts. We need to identify who should be the persons of good will taking the challenge and adding their political, intellectual, scientific capabilities and mighty for the reasons of the an ordinate human destiny. The international community have to take an action worldwide to reshape the UN and its political and operative roles. The so-called global issues are definitely the ones requesting a global governance, interdependence of International Relations with finance, economy, technology, research, peace and conflicts in the new scenario with advanced knowledge until a few years ago unimaginable, new military mighty introduced by innovation must be some of the crucial challenges, where also our Journal Global Policy and Governance intends to contribute opening its pages, issue after issue, to faculty, experts, testimonies, articles and relevant review of books, researches and working papers. We intend to embrace and reach all the possible interested colleagues and fellows around the world, as choices and strategies in all the sectors involving public and private governance, nobody excluded, are under questioning and innovative evaluation. Global world is not anymore, a provocative statement and the real antagonist of utopian return to nationalism, sovranism and the theories dominant before the treaty of Rome in 1956 and the European Union from the founders to the EU 27. Middle East, Black Sea, Eurasia, Ukraine, Baltic, Turkey have the capability to reshape the future. But why looking globally, the event of the last 50 years development and raising growth and international roles of China, India and even before Japan impose a new approach to leading players as US, European Union and new emerging countries in Latin America and Africa, where similar problems we have encountered in our complex transition seasons during the last previous century of the Eurasian continental emersion, with a relevance both for Transatlantic relations and the Asian contemporary competitive reality while the problematic Middle East still remains a factor of permanent instability and danger as we are in part still acing nowadays. The needs of evolutions and political solutions to reforming and giving voice and accountability to all the emerging countries emerged with their billions of inhabitants. We really have to rethink the International Relations and the theories of Global Governance and Policy choices, accepting the pluralism of institutional architectures and ways to give voice and accountability to their citizens. The European Union represents a “non-Statehood” institutional governance, without even a traditional Constitution and with the sovereignty belonging to the member countries. This absence of typical institutional factors that characterized the international relations of the traditional powers of the last previous century had not impeded to European Union to adopt an architecture established by the Treaty of Rome, in front of which the rest of the world was mainly sceptic until the reunification of Germany and the collapse of URSS. The illusion of the antagonists of the different European strategies and policies adopted even more with the successful the unique currency Euro and the high welfare and technologic standards already achieved by European countries. Even now, in presence of the pandemic virus hitting progressively since 2019 almost European Union countries had shown the best governance and control of the COVID-19 while all the continents, To add a valuable contribution to this scientific debate is our very aim and scope.